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HYB 051-04-02 has specificity for human fibrinogen.
HYB 051-04-02 has been successfully used in ELISA and Western blot procedures. HYB 051-04-02 reacts strongly with fibrinogen. Strong reaction is seen in ELISA with factor VIII HP directly coated onto the microtiter well, also when tested in sandwich ELISA in combination with a polyclonal antibody against fibrinogen. In Western blotting after SDS-PAGE, HYB 051-04-02 reacts with fibrinogen in non-reduced form only.
The HYB 051-04-02 immunogen is fibrinogen isolated from human plasma.
Epitope specificity of HYB 051-04-02 differs from that of HYB 051-07-02 as determined by inhibition ELISA.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。